The blockbuster medication Celexa, which is in the SSRI category of medications and is regularly used to lower cholesterol, has recently been found to effectively treat depression in patients with coronary heart disease.
François Lespérance, M.D., of the University of Montréal told the Journal of the American Medical Association that "Celexa yielded a 31% greater response rate than placebo, but the addition of interpersonal psychotherapy did not increase the benefit."
Coronary artery disease and depression have been proven to be a deadly combination. Patients suffering from the two symptoms together have a higher rate of death than those suffering from just one of the ailments.
Medpagetoday.com states, "In the study, patients were randomized to Celexa or placebo and psychotherapy or standard medical management visits for 12 weeks. The 284 outpatients randomized to one of the four treatment arms all met DSM-IV criteria for moderate-to-severe major depression as well as stable coronary artery disease."
After 12 weeks of treatment, the study found that those that took Celexa had a much larger remission rate than the other methods of treatment. Medpagetoday.com also states, "The exploratory outcomes for depressive severity, perceived social support, and function in daily activities also supported significant benefit for Celexa over placebo but not for psychotherapy over clinical management. The lack of benefit from psychotherapy compared with clinical management does not imply that other forms of psychotherapy, particularly cognitive behavioral therapy, are ineffective, the researchers said. Celexa appeared to be safe for coronary artery disease patients with depression. There were only 12 cardiovascular and 23 non cardiovascular serious adverse events among the 284 patients overall."
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