Some people are more prone to suffer from depression easily because of their own biological structure. This brings greater suffering to those affected than those who do not have these dangerous factors. There are four major biological factors that maximize possibility of depression to a person. These include biochemical factors, genetic factors, sleep irregularities and alterations in hormonal flow.
The brain consists of billions of neurons. It is also a highly complicated organ. There are many proofs telling that depression is a chemical or biological disorder. This is where the central nervous system neurotransmitter irregularities are likely the reason of clinical depression.
Moreover, these neurotransmitter irregularities can be the outcome of environmental or inherited factors or other medical conditions like hypothyroidism, cerebral infarction, AIDS, or substance mistreatment.
The brain's specific neurotransmitters are thought to be associated with mood altered parts. It was first believed that the two major neurotransmitters included were norepinephrine and serotonin.
Recent studies show that depression is a result of the malfunctioning of various neurotransmitter systems together with norepinephrine and serotonin. Furthermore, the acetylcholine, dopamine, and GABA systems are also part of the pathophysiology of main depression.
Examinations tested with twins have presented that genetic factors perform a part in the growth of depressive disorders. The average rate of split mood problems among identical twins is 45 percent to 60 percent according to a large number of examinations conducted.
Therefore, when one half of the twin experiences depression or any other mood swing, there is a 45 percent to 60 percent possibility that the other will also suffer. However, dissimilar issue may happen in the fraternal twins where the percentage falls severely to only 12 percent.
Mood swings are hereditary for some. This also justifies that those who are genetically subject to mood swings may have an earlier age of inception. It increases the chances of getting other disorders and become more prone to frequent sicknesses. However, any visible genetic factors should coordinate with environmental factors for the improvement of depression.
Sleep electroencephalogram irregularities can be proven in 40 percent to 60 percent of outpatients and up to 90 percent of inpatients during the main depressive occurrence. People have depression tend to experience a slow delta wave sleep, pre-mature absence of sleep, and altered fast eye movement latency.
The state of fast eye movement sleep together with dreaming happens in two thirds of people with bipolar and main depressive sickness. This is the decreased fast eye movement latency. This is also fixed with the expected appearance of an inherited characteristic.
Decreased fast eye movement latency and shortages in slow-wave sleep basically continue following recovery from a depressed situation. Data also recommended that depressed patients without this notice are not subject to respond to healing with tricyclic antidepressants. This contains early fast eye movement sleep.
Alterations in Hormonal Flow
Hormones act a responsibility in depression according to the inconclusive proof. The recent research about neuroendocrine characteristics related to depression has been hyperactivity of the hypothalamic-pituitary-adrenal cortical access.
The proof of intensified cortisol secretion is obvious in 20 percent to 40 percent of depressed outpatients and 40 percent to 60 percent of depressed inpatients. Additionally, outcome of a dexamethasone suppression examinations are irregular in about 50 percent of patients with depression. This refers to the hyperactivity of the hypothalamic-pituitary adrenal cortical axis.
Therefore, the result of this examination can also be irregular in people with obsessive-compulsive abnormalities and other medical states. More importantly, patients with psychotic main depression are among those with the highest scales of cortisol's nonsuppression on the dexamethasone suppression examination.