This is a very personal question with a very personal answer. At risk of taking the easy way out, there is no right or wrong time to accept that you are unlikely, or unable, to ever get pregnant. Each individual or couple will make this decision for themselves. Before you decide to accept it, though, make sure you discuss the matter with a fertility specialist in your area. This should be your first stop if you're struggling to get pregnant for six months to a year. The specialist will conduct tests and determine what could be causing your struggles. Of course, remember that as women enter their forties their chances of conception decline.
As you struggle to get pregnant, there will be some people in your life who encourage you to keep trying and never stop hoping. Others are going to tell you to accept that you will not get pregnant. So who do you listen to? Well, your doctor, for one. But also remember that while you may trust the opinion of some people in your life, it is ultimately your decision. If you decide that you can accept not getting pregnant, then walking away from treatment and procedures may be easier. In some cases, it's going to be difficult to accept it, but some come to the realization that they have to.
Months or even years of fertility treatment can wear on a person. Not only are some of the procedures invasive and require a large financial commitment, the emotional toll can be unbearable for some who face negative pregnancy test after negative pregnancy test. It's enough to send some into a depression. The stress and anxiety may even further inhibit your fertility, making it more difficult to become pregnant.
If you decide that it's time to accept that you are unlikely to ever become pregnant, adoption may be an option. Talk with your fertility specialist about your decision, and look into adoption services to see if you qualify. Adopting can be very rewarding, as not only will you get the opportunity to become parents, you will help a child in need. Some also look into surrogacy in which another individual carries a child for you. The embryo is created using donor sperm and eggs, or those of you and your partner. For some, they get pregnant naturally after giving up fertility treatment, perhaps because they relieve themselves of the stress involved with the process.